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What will be the renal clearance if the rate of urinary excretion is 625 ml/min and plasma drug concentration is 4.2 ng/ml?

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What will be the renal clearance if the rate of urinary excretion is 625 ml/min and plasma drug concentration is 4.2 ng/ml?

(a) 148.80ml^2/ng min

(b) 150ml^2/ng min

(c) 152ml^2/ng min

(d) 140ml^2/ng min

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Question is from Drugs Excretion topic in section Prodrugs & Excretion of Drugs of Drug Biotechnology

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Correct choice is (a) 148.80ml^2/ng min

Easiest explanation: Renal clearance is defined as the volume of blood which is completely cleared of the unchanged drug by the kidney. It is expressed as the rate of urinary excretion/plasma drug concentration. Thus the answer is 625/4.2 = 148.80 ml^2/ng min.

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