Question

What is the name of the drug binding site II of HSA?

(a) Tamoxifen binding site

(b) Digitoxin binding site

(c) Diazepam binding site

(d) Warfarin and azapropazone binding site

I have been asked this question in a job interview.

This interesting question is from Plasma Protein Drug Binding in chapter Protein Binding of Drugs of Drug Biotechnology

Answer 1

Right option is (c) Diazepam binding site

The best explanation: In the structure of HSA there 4 main binding sites for drugs. The 2nd drug binding site is Diazepam binding site. Drugs that binds to this site includes benzodiazepines, medium chain fatty acids, cloxacillin, probenecid, tryptophan, ketoprofen, ibuprofen, etc.