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Bioavailability of glutathione in the body doesn’t determine the threshold of a toxic response.

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Bioavailability of glutathione in the body doesn’t determine the threshold of a toxic response.

(a) True

(b) False

I got this question in exam.

My question is based upon Bioactivation and Tissue Toxicity in chapter Biotransformation of Drugs of Drug Biotechnology

1 Answer

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Correct option is (b) False

For explanation I would say: The generation of reactive metabolites is indicated by modification in enzyme activities, the formation of glutathione conjugates and depletion of tissue levels of glutathione. Thus, the bioavailability of glutathione in the body determines the threshold of a toxic response.

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