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How are free radicals generated in the human body?

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How are free radicals generated in the human body?

(a) Through cytochrome P-450 system

(b) NADPH cytochrome P-450 reductase

(c) NADPH reductase

(d) Through cytochrome P-350 system

I had been asked this question in an interview for internship.

The above asked question is from Bioactivation and Tissue Toxicity topic in portion Biotransformation of Drugs of Drug Biotechnology

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The correct answer is (b) NADPH cytochrome P-450 reductase

Explanation: Free radicles are formed via NADPH cytochrome P-450 reductase or other Flavin containing reductases. Quinones, arylamines, nitroaryls and carbon tetrachloride are some of the examples of xenobiotics which yields free radicals. Endogenous compounds such as epinephrine, DOPA can generate free radicals.

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