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The XXY klinefelter survive but trisomy in most autosome is lethal. Why?

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The XXY klinefelter survive but trisomy in most autosome is lethal. Why?

(a) Autosome carries more genes

(b) Autosomes have better dominant recessive relations

(c) X chromosomes are inactivated

(d) Autosomes are more in number

The question was posed to me in an online interview.

This interesting question is from Dosage Compensation Mechanism for X linked Genes in division Chromosomes and Sex Determination of Cytogenetics

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Right choice is (c) X chromosomes are inactivated

To explain: Due to dosage compensation only one X chromosome in XXY says active. So the effect of excess X chromosome is somewhat mitigated. In autosome there is no such inactivation and excess of gene products leads to lethality.

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