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Which of the following is true for cells with DNA damage?

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in Cytogenetics by (679k points)
Which of the following is true for cells with DNA damage?

(a) P53 binds to Mdm 2

(b) Mdm2 is prosphorylated

(c) p53 acts as transcription factor for Bad

(d) p53 is ubiquinylated

The question was asked in an online quiz.

My question is from Apoptosis and Cancer topic in section Cancer Biology & Methods in Cytogenetics of Cytogenetics

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Correct option is (b) Mdm2 is prosphorylated

To explain: In cells with DNA damage chk1 and chk2 kineses phosphorylated Mdm2. Phosphorylated Mdm2 can no longer bind p53 whose level now rises.

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