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Akt doesn’t phosphorylate ________________

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Akt doesn’t phosphorylate ________________

(a) Bad

(b) FOXO

(c) Gsk -3

(d) Caspases

This question was posed to me in an interview for job.

Asked question is from Apoptosis and Cancer in portion Cancer Biology & Methods in Cytogenetics of Cytogenetics

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Right choice is (d) Caspases

To explain: Akt is an inhibitory src kinase that is activated downstream of anti- apoptotic pathway. This phosphorylates bad and FOXO generating 14-3-3 protein binding site, and also phosphorylates Gsk-3. But it doesn’t phosphorylate caspases.

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