Question

Which one of the following sentences will be the actual definition of distribution?

(a) Transfer of drug from the administration dosage to surrounding fluid

(b) Transfer of drug from the surrounding the fluid to the blood

(c) Transfer of the drug from the oral cavity to the intestine

(d) Reversible transfer of drug between blood and extravascular fluids and tissues

This question was addressed to me in an interview.

The doubt is from Drug Distribution in portion Distribution of Drugs of Drug Biotechnology

Answer 1

The correct choice is (d) Reversible transfer of drug between blood and extravascular fluids and tissues

Easy explanation: Distribution is the reversible transfer of a drug between the blood and the extravascular fluids and tissues. The driving force for absorption is the concentration gradient.