Question

What should be the molecular weight of the drug molecules so that they can easily pass through the membrane?

(a) 600-800 Dalton

(b) 500-600 Dalton

(c) 300-500 Dalton

(d) 200-400 Dalton

The question was posed to me at a job interview.

I'm obligated to ask this question of Drug Distribution topic in division Distribution of Drugs of Drug Biotechnology

Answer 1

Correct answer is (b) 500-600 Dalton

The explanation is: Drugs with molecular weight less than 500-600 Daltons can easily cross the capillary membrane and diffuse into the extracellular interstitial fluids. Molecular size, ionization constant, and lipophilicity control the penetration of drugs from the extracellular fluid to the cells.