Question

What is therapeutic equivalence?

(a) Two or more drug products contain the same labeled chemical substance in the same amount

(b) Two or more drug products contain the same labeled chemical substance in different quantity

(c) Two or more drug products contain the same labeled chemical substance giving the same therapeutic effect

(d) Two or more drug products contain the same labeled chemical substance giving a different therapeutic effect

The question was posed to me during an internship interview.

My doubt is from Bioequivalence Studies topic in section Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer 1

Correct choice is (c) Two or more drug products contain the same labeled chemical substance giving the same therapeutic effect

To explain I would say: When two or more drug products contain the same therapeutically active ingredient which elicits the same pharmacological effects and can control the disease to the same extent are known to have therapeutic equivalence. Bioequivalence is a relative term which denotes that the drug substance reaches the systemic circulation at the same relative rate or time and to the same extent when given in two or more identical dosage.