Question

What will be the particle size after micronization of drugs?

(a) 1-10 micron

(b) 10-20 micron

(c) 20-30 micron

(d) 1-5 micron

I had been asked this question in an online interview.

My doubt stems from Bioavailability topic in section Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

Answer 1

Right answer is (a) 1-10 micron

The best explanation: Micronization is a process where the size of the solid drug particles is reduced to 1-10 microns by spray drying or by using air attrition methods. Drugs such as griseofulvin and several steroidal and sulfa drugs are there whose bioavailability is increased by micronization.