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Which drugs cannot be filtered through glomerulus?

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Which drugs cannot be filtered through glomerulus?

(a) Drugs bound to plasma proteins

(b) Unbound

(c) Free drug

(d) Below molecular weight of 300 Dalton

This question was posed to me during an online interview.

This interesting question is from Drugs Excretion in division Prodrugs & Excretion of Drugs of Drug Biotechnology

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Right option is (a) Drugs bound to plasma proteins

To explain: Drugs that are bound to plasma behave as macromolecules don’t get filtered through the glomerulus. Unbound free drug which are less than 300 Dalton get filtered by the glomerulus.

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