Question

Which are the drugs for 1^st line treatment of hypertension?

(a) Diuretic

(b) Angiotensin-converting enzyme inhibitor

(c) Increase drug dose

(d) Need further studies

I had been asked this question during an online exam.

This interesting question is from Histamine, Bradykinin and Their Antagonists topic in portion Histamine, Bradykinin and their Antagonists, Pharmacotherapy of Gastric Ulcer, Peptic Ulcer of Drug Biotechnology

Answer 1

The correct option is (a) Diuretic

Easiest explanation: 1^st line treatment should continue with lifestyle modification, initial drug selection should be diuretic, beta-blocker. If inadequate, continue to second-line treatment which includes adding drugs such as Angiotensin Converting Enzyme (ACE) Inhibitor, Calcium Channel Blocker. If inadequate, continue to third line treatment increase drug dose or Substitute another drug or add a second drug from another class. If inadequate may need to do further studies serious organ damage may be present.