Question

Which are the drugs for 2^nd line treatment of hypertension?

(a) Diuretic

(b) Angiotensin-converting enzyme inhibitor

(c) Increase drug dose

(d) Need further studies

I had been asked this question in homework.

My question comes from Histamine, Bradykinin and Their Antagonists in portion Histamine, Bradykinin and their Antagonists, Pharmacotherapy of Gastric Ulcer, Peptic Ulcer of Drug Biotechnology

Answer 1

The correct option is (b) Angiotensin-converting enzyme inhibitor

The explanation: Second-line treatment which includes adding drugs such as Angiotensin Converting Enzyme (ACE) Inhibitor, Calcium Channel Blocker, Angiotensin II Receptor Blocker (ARB), α- blocker, α- and β-blocker. And line should be given when 1^st line treatment with lifestyle modification, initial drug selection should be diuretic, beta-blocker is in adequate. If 2^nd line treatment is inadequate, continue to third line treatment increase drug dose or Substitute another drug or add a second drug from another class. If inadequate may need to do further studies serious organ damage may be present.