Question

In the given picture of a graph plotted between the plasma concentration versus time, the marked curve is for which kind of dosage?

(a) Larger dose

(b) Optimum dose

(c) Smaller dose

(d) Lethal dose

I got this question during a job interview.

I'm obligated to ask this question of Pharmacokinetic Principles Applications topic in portion Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology

Answer 1

Correct choice is (a) Larger dose

Easiest explanation: The marked curve is the curve showing larger dose profile. Greater the dose, greater the fluctuations during each dosing interval and greater the chances of toxicity. The graph shows both therapeutic and toxic responses. The curve in the middle is for optimum dose profile. The curve below that is for smaller dose profile.