Question

Accumulation occurs because drug from previous doses was not being removed completely.

(a) True

(b) False

This question was addressed to me in class test.

Query is from Pharmacokinetic Principles Applications in chapter Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology

Answer 1

Right option is (a) True

The best I can explain: The given statement is completely true. Accumulation of any drug occurs because the previous amount of drug was not being completely removed from the body. As the amount of drug in the body rises due to accumulation, the rate of elimination also rises proportionally until a steady-state or plateau is reached when the rate of drug entry into the body equals the rate of exit.