Question

Which of the following drugs is Proton pump inhibitor?

(a) Cimetidine

(b) Omeprazole

(c) Pirenzepine

(d) Misoprostol

This question was addressed to me at a job interview.

This interesting question is from Pharmacotherapy of Peptic Ulcer topic in portion Histamine, Bradykinin and their Antagonists, Pharmacotherapy of Gastric Ulcer, Peptic Ulcer of Drug Biotechnology

Answer 1

The correct option is (b) Omeprazole

The best I can explain: H2 receptor blockage antihistamine function by reducing gastric acid secretion. H2 antihistamines are cimetidine. Proton pump inhibitor will be omeprazole, lansoprazole, pantoprazole. These drugs goes and binds to the proton pumps thus inhibiting further release of any protons to produce acids.