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Inhibition of H^+, K^+-ATPase blocks both basal and stimulated acid secretion.

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Inhibition of H^+, K^+-ATPase blocks both basal and stimulated acid secretion.

(a) True

(b) False

I got this question in exam.

Question is from Pharmacotherapy of Peptic Ulcer topic in section Histamine, Bradykinin and their Antagonists, Pharmacotherapy of Gastric Ulcer, Peptic Ulcer of Drug Biotechnology

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The correct answer is (a) True

For explanation I would say: H^+, K^+-ATPase is located in the apical membrane of the oxyntic cell along the secretory canaliculi. The pump requires large amounts of energy that is supplied by intracellular ATP that is why inhibition of H^+, K^+-ATPase blocks both basal and stimulated acid secretion.

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