Question

APC cells present ______________ antigen to T cells.

(a) Axon

(b) Myelin

(c) Actin

(d) Oligodendrocytes

I have been asked this question during an interview.

My question is taken from Biopharmaceuticals topic in chapter Biopharmaceuticals of Drug Biotechnology

Answer 1

Correct answer is (b) Myelin

To elaborate: APC cells present myelin antigen to T-cells. These t cells pass through the BBB. Normally BBB prevents the passage of potentially harmful substances through blood vessel walls within the brain. But MS patients’ BBB ‘springs a leak’ which tends to allow all the activated t cells across the BBB which attack the myelin sheath.