Question

What is the strength of salt bridges?

(a) 10-15 kcal/mol

(b) 20-25 kcal/mol

(c) 17-20 kcal/mol

(d) 4-7 kcal/mol

I had been asked this question during an online interview.

My doubt stems from Biopharmaceuticals in portion Biopharmaceuticals of Drug Biotechnology

Answer 1

Correct answer is (d) 4-7 kcal/mol

Best explanation: The energy needed to break a salt bridge is around 4-7 kcal/mol. Salt bridges are electrostatic bonds between oppositely charged groups. The ions on the R group of amino acids form salt bridges through electrostatic bonds.