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Which polypeptide of cholera enterotoxin is nontoxic but immunogenic?

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Which polypeptide of cholera enterotoxin is nontoxic but immunogenic?

(a) A1

(b) A2

(c) B

(d) B1

I had been asked this question by my college director while I was bunking the class.

My question comes from Immunological Preparations in chapter Immunological Preparations of Drug Biotechnology

1 Answer

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Correct answer is (c) B

The explanation is: Cholera enterotoxin (produced by Vibrio cholerae) consists of three polypeptides: A1, A2 and B polypeptides. The A polypeptides are toxic, while the B polypeptide is nontoxic but immunogenic. Thus, we can use the B polypeptide for the manufacture of vaccines.

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