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Which of the following enzyme is inhibited by Fluoroacetate in Krebs cycle?

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Which of the following enzyme is inhibited by Fluoroacetate in Krebs cycle?

(a) Citrate synthase

(b) Aconitase

(c) Isocitrate dehydrogenase

(d) Fumarase

I got this question in an online interview.

Asked question is from Respiration in section Bioenergetics and Metabolism of Life Sciences

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Best answer
The correct choice is (b) Aconitase

The best explanation: Fluoroacetate is a potent inhibitor of aconitase enzyme; it is a pesticide which blocks citric acid cycle by its metabolic conversion to fluorocitrate.

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