Question

Which of the following statement is INCORRECT about superantigens?

(a) Viral or bacterial proteins

(b) Endogenous by nature

(c) Unique binding ability

(d) Activate a large number of T-cells

I had been asked this question in semester exam.

Question is from Major Histocompatibility Complex in section Immunology of Life Sciences

Answer 1

Right option is (b) Endogenous by nature

Explanation: Superantigens are viral or bacterial proteins which have the unique binding ability of T-cell receptor and MHC II molecules, i.e. it binds simultaneously to both and activate large numbers of T-cells. It can be both either endogenous or exogenous in nature.