Question

Which of the following is NOT true for loss of function mutation?

(a) Usually recessive

(b) Most common mutation

(c) Increases the activity of the gene

(d) Null allelic mutation

This question was addressed to me in an interview for job.

Enquiry is from Mutation in chapter Molecular Genetics of Life Sciences

Answer 1

Correct choice is (c) Increases the activity of the gene

To explain: Loss of function mutation either reduce or abolishes the activity of a gene. On the contrary mutation that increases the activity of the gene is called a gain of function mutation.