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If DNA is damaged, which of the following gene arrest cell cycle?

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If DNA is damaged, which of the following gene arrest cell cycle?

(a) Rb

(b) p53

(c) Hedgehog receptor

(d) p16

This question was posed to me during an online exam.

This intriguing question comes from Cancer topic in section Cell Structure and Functions of Life Sciences

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Correct answer is (b) p53

The explanation: p53 is a tumor suppressor gene which acts as a transcription factor and arrests the cell cycle if DNA is damaged. These genes also encode checkpoint control proteins and maintain genomic stability during mitotic proliferation.

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