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Which of the following chromosomal alteration causes retinoblastoma?

(a) Deletion in chromosome 11

(b) Translocation between chromosome 9 and 22

(c) Deletion in chromosome 13

(d) Translocation between chromosome 8 and 21

This question was posed to me in a national level competition.

My question is from Cancer topic in chapter Cell Structure and Functions of Life Sciences

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Correct answer is (c) Deletion in chromosome 13

The explanation is: Retinoblastoma is an eye cancer which is caused by the deletion in chromosome number 13. Wilms tumor caused due to deletion in chromosome 11 and leukemia is caused by the translocation between the segments of chromosomes.

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