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Which of the following groups of amino acids are least soluble in water?

(a) Polar

(b) Non-polar

(c) Polar charged

(d) Polar uncharged

I had been asked this question during an interview.

My doubt is from Chemical Basis of Life in division Chemical Basis of Life of Cell Biology

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Right answer is (b) Non-polar

The explanation: Non-polar amino acids have side chains that are essentially hydrocarbons(sulphur in case of methionine and cysteine). This causes the amino acid water interaction to be weak and thus are sparsely soluble in water. The amino acids included in this category are alanine, valine, leucine, isoleucine, tryptophan, phenylalanine and methionine. Phenylalanine is least soluble due to its bulky aromatic side chain.

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