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Chaperones bind to which type of amino acid residues in the protein?

(a) Charged

(b) Uncharged

(c) Hydrophobic

(d) Hydrophilic

The question was posed to me during an online exam.

The question is from Chemical Basis of Life in section Chemical Basis of Life of Cell Biology

1 Answer

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Correct answer is (c) Hydrophobic

Easy explanation: Chaperons are helper proteins that binds to hydrophobic amino acid residues that are part of the core of the folded protein. In the denatured state the core amino acid residues are exposed which is identified. Once bound the polypeptide molecule is folded like a hairpin into its tertiary state.

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