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The Dayhoff model of protein evolution is not a Markov process.

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The Dayhoff model of protein evolution is not a Markov process.

(a) True

(b) False

The question was posed to me during an internship interview.

Asked question is from Use of Scoring Matrices and Gap Penalties in Sequence Alignments in portion Sequence Alignment of Bioinformatics

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Right answer is (b) False

The best explanation: The Dayhoff Model of Protein Evolution as Used in PAM Matrices is a Markov process. In Analysis of the Dayhoff Model, each amino acid site in a protein can change at any time to any of the other 20 amino acids with probabilities given by the PAM table, and the changes that occur at each site are independent of the amino acids found at other sites in the protein and depend only on the current amino acid at the site.

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