Question

Which of the following is wrong in case of substitution matrices?

(a) They determine likelihood of homology between two sequences

(b) They use system where substitutions that are more likely should get a higher score

(c) They use system where substitutions that are less likely should get a lower score

(d) BLOSUM-X type uses logarithmic identity to find similarity

The question was asked by my college professor while I was bunking the class.

I need to ask this question from Global Sequence Alignment topic in division Sequence Alignment of Bioinformatics

Answer 1

The correct choice is (d) BLOSUM-X type uses logarithmic identity to find similarity

The best explanation: BLOSUM-X type identifies sequences that are X% similar to the query sequence i. e. score 54 corresponds to 54% similarity hence reducing the complexity of the output and giving the similarity in percentage. Also, these matrices are popular in bioinformatics due to their speed and accuracy.