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The higher is the score in the alignment _________

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The higher is the score in the alignment _________

(a) the more significant is the alignment

(b) or the less it resembles alignments in related proteins

(c) the less significant is the alignment

(d) the less it aligns with the related protein sequence

The question was posed to me during an online interview.

The question is from Dynamic Programming Algorithm for Sequence Alignment topic in division Sequence Alignment of Bioinformatics

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Correct choice is (a) the more significant is the alignment

The best explanation: In the scoring system, the higher this score, the more significant is the alignment, or the more it resembles alignments in related proteins. Also, the score given for gaps in aligned sequences is negative, because such misaligned regions should be uncommon in sequences of related proteins. Such a score will reduce the score obtained from an adjacent, matching region upstream in the sequences.

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