Question

Which of the following statements about InterPro is incorrect regarding its features?

(a) Protein relatedness is defined by the P-values from the BLAST alignments

(b) The most closely related sequences are grouped into the lowest level clusters

(c) More distant protein groups are merged into higher levels of clusters

(d) The outcome of this cluster merging is a tree-like structure of functional categories

This question was posed to me in unit test.

The above asked question is from Protein Family Databases in chapter Sequence Alignment of Bioinformatics

Answer 1

Correct choice is (a) Protein relatedness is defined by the P-values from the BLAST alignments

The best I can explain: InterPro is a database of clusters of homologous proteins similar to COG. Protein relatedness is defined by the E-values from the BLAST alignments. The database further provides gene ontology information for protein cluster at each level as well as keywords from InterPro domains for functional prediction.