Question

Which of the following statements about SCOP is incorrect regarding its features?

(a) Proteins with the same shapes but having little sequence or functional similarity are placed in different super families, and are assumed to have only a very distant common ancestor

(b) Proteins having the same shape and some similarity of sequence and/or function are placed in ‘families’, and are assumed to have a closer common ancestor

(c) SCOP was created in 1994 in the Centre of Protein Engineering and the University College London

(d) It aims to determine the evolutionary relationship between proteins

The question was posed to me in an online quiz.

This intriguing question originated from Protein Family Databases topic in section Sequence Alignment of Bioinformatics

Answer 1

The correct answer is (c) SCOP was created in 1994 in the Centre of Protein Engineering and the University College London

The best explanation: SCOP, Structural Classification of Proteins, was created in 1994 in the Centre of Protein Engineering and the Laboratory of Molecular Biology. It was maintained by Alexey G. Murzin and his colleagues in the Centre for Protein Engineering until its closure in 2010 and subsequently at the Laboratory of Molecular Biology in Cambridge, England.