If the score is located in the extreme margin of the distribution, that means that the alignment between the two sequences is ______ due to random chance and is thus considered ______
(a) unlikely, significant
(b) unlikely, insignificant
(c) unlikely, insignificant
(d) very likely, significant
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My question comes from Statistical Significance of Sequence Alignment topic in division Pairwise Sequence Alignment of Bioinformatics