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The major disadvantage of the PRSS program is that it doesn’t allow partial shuffling.

(a) True

(b) False

This question was addressed to me in examination.

This key question is from Statistical Significance of Sequence Alignment topic in division Pairwise Sequence Alignment of Bioinformatics

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Best answer
The correct answer is (b) False

Best explanation: The major feature of the program is that it allows partial shuffling. For example, shuffling can be restricted to residues within a local window of 25–40, whereas the residues outside the window remain unchanged.

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