Question

The next step in the pairwise energy based method is to build a crude model for the target sequence by replacing aligned residues in the template structure with the corresponding residues in the query.

(a) True

(b) False

The question was posed to me at a job interview.

This key question is from Threading and Fold Recognition topic in division Protein Tertiary Structure Prediction of Bioinformatics

Answer 1

The correct option is (a) True

Easy explanation: After the mentioned step, the last step is to calculate the energy terms of the raw model, which include pairwise residue interaction energy, solvation energy, and hydrophobic energy. Finally, the models are ranked based on the energy terms to find the lowest energy fold that corresponds to the structurally most compatible fold.