Question

Which of the following is untrue about profile method?

(a) A profile is constructed for a group of related protein structures

(b) The propensity of amino acids in not in picture of this method

(c) Statistical information from these aligned residues is then used to construct a profile

(d) The structural profile is generated by the superimposition of the structures to expose corresponding residues

I have been asked this question during an online exam.

Query is from Threading and Fold Recognition topic in section Protein Tertiary Structure Prediction of Bioinformatics

Answer 1

The correct answer is (b) The propensity of amino acids in not in picture of this method

The best I can explain: The profile contains scores that describe the propensity of each of the twenty amino acid residues to be at each profile position. The profile scores contain information for secondary structural types, the degree of solvent exposure, polarity, and hydrophobicity of the amino acids. To predict the structural fold of an unknown query sequence, the query sequence is first predicted for its secondary structure, solvent accessibility, and polarity.