Question

Threading or structural fold recognition predicts the structural fold of an unknown protein sequence by fitting the sequence into a structural database and selecting the best-fitting fold.

(a) True

(b) False

I got this question in unit test.

My doubt is from Threading and Fold Recognition in portion Protein Tertiary Structure Prediction of Bioinformatics

Answer 1

Correct option is (a) True

The best explanation: To determine whether a protein sequence adopts a known three-dimensional structure fold relies on threading and fold recognition methods. The comparison emphasizes matching of secondary structures, which are most evolutionarily conserved. Therefore, this approach can identify structurally similar proteins even without detectable sequence similarity.