Question

Which of the following is not correct about the Coils and Loops?

(a) They are regular structures

(b) They are irregular structures

(c) The loops are often characterized by sharp turns or hairpin-like structures

(d) If the connecting regions are completely irregular, they belong to random coils

This question was posed to me in quiz.

This is a very interesting question from Protein Structure Basics in division Structural Bioinformatics of Bioinformatics

Answer 1

The correct choice is (a) They are regular structures

To explain I would say: Residues in the loop or coil regions tend to be charged and polar and located on the surface of the protein structure. They are often the evolutionarily variable regions where mutations, deletions, and insertions frequently occur. They can be functionally significant because these locations are often the active sites of proteins.