Question

The dot matrix method and the dynamic programming method can be used in detecting self-complementary regions of a sequence.

(a) True

(b) False

The question was asked during an internship interview.

Question is taken from RNA Secondary Structure Prediction Methods topic in division RNA Structure Prediction of Bioinformatics

Answer 1

Correct option is (a) True

Explanation: A simple dot matrix can find all possible base-paring patterns of an RNA sequence when one sequence is compared with itself. In this case, dots are placed in the matrix to represent matching complementary bases instead of identical ones.