Question

The scoring scheme based on the combined stabilizing and destabilizing interactions forms the foundation of the ab initio RNA secondary structure prediction method.

(a) True

(b) False

I have been asked this question in a national level competition.

The above asked question is from RNA Secondary Structure Prediction Methods in chapter RNA Structure Prediction of Bioinformatics

Answer 1

Correct choice is (a) True

Explanation: Parameters for calculating different destabilizing energies have also been determined and can be used as penalties for secondary structure calculations. This method works by first finding all possible base-pairing patterns from a sequence and then calculating the total energy of a potential secondary structure by taking into account all the adjacent stabilizing and destabilizing forces.