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The first step in Genetic Algorithm is arranging the sequences to be aligned in rows.

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The first step in Genetic Algorithm is arranging the sequences to be aligned in rows.

(a) True

(b) False

I got this question in an online interview.

Query is from Iterative Methods of Multiple Sequence Alignment in chapter Multiple Sequence Alignment of Bioinformatics

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Correct choice is (a) True

The explanation: The sequences to be aligned are written in rows, as on a page, except that they are made to overlap by a random amount of sequence, up to 50 residues long for sequences about 200 in length. The ends are then padded with gaps. A typical population of 100 of these MSAs is made, although other numbers may be set.

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