Question

Which of the following is untrue about SCOP?

(a) It is a database for comparing and classifying protein structures

(b) It is constructed almost entirely based on manual examination of protein structures

(c) The proteins are grouped into hierarchies of classes, folds, superfamilies, and families

(d) The SCOP families consist of proteins having low sequence identity (>30%)

This question was addressed to me in a national level competition.

My question is from Protein Structure Classification in section Structural Bioinformatics of Bioinformatics

Answer 1

The correct answer is (d) The SCOP families consist of proteins having low sequence identity (>30%)

To explain I would say: The SCOP families consist of proteins having high sequence identity (>30%). Thus, the proteins within a family clearly share close evolutionary relationships and normally have the same functionality. The protein structures at this level are also extremely similar.