Question

The presence of ______ signal peptides can significantly compromise the prediction _______ because the programs tend to confuse hydrophobic signal peptides with membrane helices.

(a) hydrophobic, accuracy

(b) hydrophobic, error

(c) hydrophilic, accuracy

(d) hydrophilic, error

The question was posed to me during an online exam.

I want to ask this question from Secondary Structure Prediction for Transmembrane Proteins in section Secondary Structure Prediction of Bioinformatics

Answer 1

Correct option is (a) hydrophobic, accuracy

Explanation: Predicting transmembrane helices is relatively easy. The accuracy of Some of the best predicting programs, such as TMHMM or HMMTOP, can exceed 70%. To minimize errors, the presence of signal peptides can be detected using a number of specialized programs and then manually excluded.