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Members within the ____ fold ______ have evolutionary relationships.

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Members within the ____ fold ______ have evolutionary relationships.

(a) same, always

(b) same, do not always

(c) one, always

(d) different, do not

I got this question in a national level competition.

This interesting question is from Protein Structure Classification in section Structural Bioinformatics of Bioinformatics

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Right choice is (b) same, do not always

Easy explanation: Folds consist of superfamilies with a common core structure, which is determined manually. This level describes similar overall secondary structures with similar orientation and connectivity between them. Members within the same fold do not always have evolutionary relationships. Some of the shared core structure may be a result of analogy. Classes consist of folds with similar core structures.

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