Question

Rosetta is a web server that predicts protein three-dimensional conformations using the ab initio method.

(a) True

(b) False

The question was asked in an internship interview.

I'm obligated to ask this question of Ab Initio Protein Structural Prediction & Homology Modeling in section Protein Tertiary Structure Prediction of Bioinformatics

Answer 1

The correct choice is (a) True

Explanation: This in fact relies on a “mini-threading” method. The method first breaks down the query sequence into many very short segments (three to nine residues) and predict the secondary structure of the small segments using a Hidden Markov model–based program, HMMSTR.