Question

Which of the following is untrue about CLUSTAL program?

(a) CLUSTAL performs a global-multiple sequence alignment by a different method than MSA (Multiple Sequence Alignment)

(b) The initial heuristic alignment obtained by MSA is calculated in a different way

(c) The initial step includes performing pair-wise alignments of all of the sequences

(d) The intermediate step includes use the alignment scores to produce a phylogenetic tree

The question was asked in quiz.

I would like to ask this question from Progressive Methods of Multiple Sequence Alignment in portion Multiple Sequence Alignment of Bioinformatics

Answer 1

The correct option is (b) The initial heuristic alignment obtained by MSA is calculated in a different way

Explanation: The initial heuristic alignment obtained by MSA is calculated the same way, although it performs a global-multiple sequence alignment by a different method than MSA (Multiple Sequence Alignment). As the mentioned options are first two steps, the last is aligning the sequences sequentially, guided by the phylogenetic relationships indicated by the tree.