Question

Which of the following is untrue regarding Phobius?

(a) It is a web-based program designed to overcome false positives caused by the presence of signal peptides

(b) The program incorporates distinct HMM models for signal peptides only

(c) The program incorporates distinct HMM models for signal peptides as well as transmembrane helices

(d) After distinguishing the putative signal peptides from the rest of the query sequence, prediction is made on the remainder of the sequence

This question was addressed to me in quiz.

My enquiry is from Secondary Structure Prediction for Transmembrane Proteins topic in chapter Secondary Structure Prediction of Bioinformatics

Answer 1

The correct answer is:

(b) The program incorporates distinct HMM models for signal peptides only

Phobius is a web-based program used for predicting signal peptides and transmembrane helices in proteins. The program incorporates distinct Hidden Markov Models (HMM) for both signal peptides and transmembrane helices, not just signal peptides alone.

So, option (b) is untrue because Phobius is designed to predict both signal peptides and transmembrane helices, not just the signal peptides.