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A recent improvement in the implementation of BLAST is the ability to provide gapped alignment.

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A recent improvement in the implementation of BLAST is the ability to provide gapped alignment.

(a) True

(b) False

The question was asked in quiz.

My doubt stems from Basic Local Alignment Search Tool (BLAST) in chapter Database Similarity Searching of Bioinformatics

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The correct option is (a) True

The explanation: In gapped BLAST, the highest scored segment is chosen to be extended in both directions using dynamic programming where gaps may be introduced. The extension continues if the alignment score is above a certain threshold; otherwise it is terminated. However, the overall score is allowed to drop below the threshold only if it is temporary and rises again to attain above threshold values. Final trimming of terminal regions is needed before producing a report of the final alignment.

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