Question

Which of the following is incorrect about Multiple Structure Alignment?

(a) The alignment strategy is different than the Clustal sequence alignment using a progressive approach

(b) All structures are first compared in a pairwise fashion

(c) A distance matrix is developed based on structure similarity scores such as RMSD

(d) The aligned structures create a median structure that allows other structures to be progressively added for comparison based on the hierarchy described in the guide tree

This question was addressed to me in an interview for job.

Origin of the question is Protein Structure Comparison in section Structural Bioinformatics of Bioinformatics

Answer 1

Right answer is (a) The alignment strategy is different than the Clustal sequence alignment using a progressive approach

Explanation: In addition to pairwise alignment, a number of algorithms can also perform multiple structure alignment. The alignment strategy is similar to the Clustal sequence alignment using a progressive approach. When all the structures in the set are added, this eventually creates a multiple structure alignment.